Pre-Conference Workshop Day

Pre-Conference Workshop Day

2.00pm - 5.00pm Exploring a Novel Therapeutic Option- Insight Behind Regulation of Pathogenic T Helper Cell 17 Differentiation

Professor Sun and his team's recent work focuses on previously neglected post-translational regulation of RORgt. They have identified a sumoylation site and a ubiquitination site, and demonstrated their in vivo function by generating two strains of mice expressing RORgt with a point mutation that prevents sumoylation or ubiquitination. The both strains of mice are defective in development of Th17-mediated EAE.

This case study will explore the mechanisms responsible for post translational regulation of RORgt.

Key Takeaways:

  • This case study will explore the mechanisms responsible for post-translational regulation of RORgt
  • Exploring the role Th17 cells mediate pathological immune responses responsible for autoimmune diseases, including psoriasis and multiple sclerosis
  • Insight behind the latest case study of current therapies available that are targeting transcription factor retinoid acid–related orphan receptor g t (RORgt)
  • Utilizing this information to facilitate the development of drugs specifically targeting Th17-dependent autoimmunity

Your Workshop Leader:

Zuoming Sun, Professor, City of Hope Medical Center